RESUMO
BACKGROUND: Atopic dermatitis (AD) is most common in the first year of life. The aim of this study was to determine the prevalence of and risk factors for AD in a birth cohort of infants from southeast Turkey. METHODS: Adana Paediatric Allergy Research (ADAPAR) birth cohort study was derived from 1377 infants who were born in Cukurova University, Medical Hospital, Adana, Turkey between February 2010 and February 2011. At birth, a physical examination was performed, cord blood samples were taken, and the mother completed a baseline questionnaire that provided data on gestational conditions, family history of allergic diseases and environmental exposures. Follow-up visits scheduled at 3, 6, and 12 months included an infant physical examination and an extended questionnaire. Skin prick test was performed and food-specific IgE levels were measured at 6 and 12 months. Atopic dermatitis was diagnosed based on confirmatory examination by a physician. RESULTS: Of the 1377 infants enrolled, 59 (4.3%) were diagnosed with AD as of 12 months. Maternal allergic disease (ORs 6.28, 95% CI 1.03-38.30; p = 0.046), maternal infection during gestation (ORs 3.73, 95% CI 1.25-11.09; p = 0.018), and presence of food allergy (ORs 13.7, 95% CI 3.07-61.0; p = 0.001) were identified as risk factors for AD. Breastfeeding and cord blood IgE levels were not identified as risk factors. CONCLUSIONS: In this cohort we found prevalence of AD as 4.3% during the first year of life. Positive family history of atopic diseases, prenatal infections and presence of food allergy are the risk factors for early presentation of AD
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Assuntos
Humanos , Masculino , Feminino , Gravidez , Recém-Nascido , Lactente , Dermatite Atópica/diagnóstico , Dermatite Atópica/etiologia , Dermatite Atópica/patologia , Sangue Fetal , Hipersensibilidade Alimentar/diagnóstico , Hipersensibilidade Alimentar/prevenção & controle , Hipersensibilidade Alimentar/terapia , Fatores de Risco , Aleitamento Materno/instrumentação , Aleitamento Materno/métodos , Exame Físico/instrumentação , Exame Físico/métodos , Exame Físico , Hipersensibilidade a Leite/diagnóstico , Hipersensibilidade a Leite/imunologia , Doenças do Recém-Nascido , Recém-Nascido , Estudos de Coortes , TurquiaRESUMO
Background: In this study, we aimed to investigate the relationship between pertussis infections and allergic diseases in two cross-sectional questionnaire-based surveys carried out in 1997 and 2004. We also measured serum level of antibody to B. pertussis. Material and Methods: Two cross-sectional, questionnaire-based surveys were carried out in 1997 (n = 3164) and 2004 (n = 3728). 361 cases and 465 controls were recruited from both surveys. The skin tests were performed using standardised extracts. The level of pertussis specific IgG was measured in 136 allergic and 168 non-allergic children. Results: We found that allergic diseases prevalence was significantly higher in the children suffering from pertussis infections (22.3 % first and 8.8 % second survey) compared to children who did not suffer from pertussis infections (6.6 % first and 4.5 % second survey) (p = 0.001 and p = 0.035, respectively). Asthma prevalence was also significantly higher in children suffering from pertussis infection (37.6 % first and 26.2 % second survey) compared to children who did not suffer from pertussis (7.4 % first and 5.0 % second survey) (p = 0.001 and p = 0.001, respectively). However, the mean serum levels of anti-pertussis IgG were similar in allergic and non-allergic groups (p > 0.05). Conclusion: Although pertussis antibody levels in atopic and non-atopic children were similar to each other, pertussis infection still seemed to have a significant effect on the development of atopic diseases (AU)
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